Which condition is a contraindication for spironolactone?

Which condition is a contraindication for spironolactone?

• A. Hyperkalaemia
• B. Hypokalaemia
• C. Hyponatremia
• D. Hypomagnesemia

Answer: (A)

Spironolactone is a potassium-sparing diuretic that blocks aldosterone in the collecting ducts, reducing potassium excretion and raising potassium levels. Because of this, it is contraindicated if potassium is already high, since further increases can cause dangerous heart rhythm problems. The other conditions listed do not by themselves mandate avoiding spironolactone; they may require caution or monitoring, but hyperkalemia is the specific situation that makes this drug unsafe.

Spironolactone is a potassium-sparing diuretic that blocks aldosterone in the collecting ducts, reducing potassium excretion and raising potassium levels. Because of this, it is contraindicated if potassium is already high, since further increases can cause dangerous heart rhythm problems. The other conditions listed do not by themselves mandate avoiding spironolactone; they may require caution or monitoring, but hyperkalemia is the specific situation that makes this drug unsafe.