Which among Mrs T's medicines does not commonly cause diarrhoea?

Which among Mrs T's medicines does not commonly cause diarrhoea?

• A. Loperamide
• B. Metformin
• C. Amitriptyline
• D. Omeprazole

Answer: (C)

Diarrhoea as a side effect often comes from drugs that speed up gut transit, disrupt fluid absorption, or alter the gut environment. Metformin commonly causes diarrhoea, especially when first started, due to changes in intestinal Motility and absorption. Omeprazole can lead to diarrhoea by changing the gut flora and increasing infection risk like C. difficile. Loperamide is an anti-diarrhoeal and is used to treat diarrhoea, not cause it. Amitriptyline, on the other hand, has strong anticholinergic effects that slow bowel movements, leading to constipation rather than diarrhoea. So amitriptyline is the one that does not commonly cause diarrhoea.

Diarrhoea as a side effect often comes from drugs that speed up gut transit, disrupt fluid absorption, or alter the gut environment. Metformin commonly causes diarrhoea, especially when first started, due to changes in intestinal Motility and absorption. Omeprazole can lead to diarrhoea by changing the gut flora and increasing infection risk like C. difficile. Loperamide is an anti-diarrhoeal and is used to treat diarrhoea, not cause it. Amitriptyline, on the other hand, has strong anticholinergic effects that slow bowel movements, leading to constipation rather than diarrhoea. So amitriptyline is the one that does not commonly cause diarrhoea.