Which adverse effect is likely with semaglutide weekly injections for weight management?

Which adverse effect is likely with semaglutide weekly injections for weight management?

• A. Burping
• B. Nausea
• C. Headache
• D. Drowsiness

Answer: (A)

The effect being tested is how GLP-1 receptor agonists alter gastric motility. Semaglutide, given weekly for weight management, slows gastric emptying and increases the time the stomach holds contents. This can lead to gas buildup and a tendency to belch as the stomach releases swallowed air and gas produced during digestion. While nausea is also a known side effect of GLP-1 drugs, burping specifically reflects the slowed gastric transit and consequent gas accumulation, making it a more likely adverse effect among the options. Headache and drowsiness can occur with various medications but are not as directly tied to the gastric effects of semaglutide.

The effect being tested is how GLP-1 receptor agonists alter gastric motility. Semaglutide, given weekly for weight management, slows gastric emptying and increases the time the stomach holds contents. This can lead to gas buildup and a tendency to belch as the stomach releases swallowed air and gas produced during digestion. While nausea is also a known side effect of GLP-1 drugs, burping specifically reflects the slowed gastric transit and consequent gas accumulation, making it a more likely adverse effect among the options. Headache and drowsiness can occur with various medications but are not as directly tied to the gastric effects of semaglutide.