For an elderly patient with atrial fibrillation and no renal impairment taking edoxaban, which regimen is most appropriate?

For an elderly patient with atrial fibrillation and no renal impairment taking edoxaban, which regimen is most appropriate?

• A. 60 mg once daily
• B. 30 mg once daily
• C. 15 mg once daily
• D. 20 mg once daily

Answer: (B)

Dosing of edoxaban in atrial fibrillation is adjusted to balance preventing stroke with avoiding bleeding, based on factors that affect drug exposure and bleeding risk. The standard regimen is 60 mg once daily, but this dose is reduced to 30 mg once daily if any of the specific criteria are met: creatinine clearance is between 15 and 50 mL/min, body weight is 60 kg or less, or there is concomitant use of certain P-gp inhibitors. In an elderly patient with no renal impairment, you would normally use the standard 60 mg daily unless one of those reduction criteria is present. The choice of 30 mg daily in this scenario suggests that one such factor applies (for example, factors associated with increased bleeding risk or reduced drug exposure), making the lower dose the safer option while preserving efficacy. The other listed doses aren’t standard regimens for atrial fibrillation with edoxaban.

Dosing of edoxaban in atrial fibrillation is adjusted to balance preventing stroke with avoiding bleeding, based on factors that affect drug exposure and bleeding risk. The standard regimen is 60 mg once daily, but this dose is reduced to 30 mg once daily if any of the specific criteria are met: creatinine clearance is between 15 and 50 mL/min, body weight is 60 kg or less, or there is concomitant use of certain P-gp inhibitors. In an elderly patient with no renal impairment, you would normally use the standard 60 mg daily unless one of those reduction criteria is present. The choice of 30 mg daily in this scenario suggests that one such factor applies (for example, factors associated with increased bleeding risk or reduced drug exposure), making the lower dose the safer option while preserving efficacy. The other listed doses aren’t standard regimens for atrial fibrillation with edoxaban.